1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

Base Information

Chemical Name:1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol
CAS No.:371970-02-4
Molecular Formula:C₃₂H₃₃ClN₂O₂
Molecular Weight:513.079
Hs Code.:

Synonyms:1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

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Chemical Property of 1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

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Technology Process of 1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

There total 3 articles about 1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51135-96-7
4-benzyl-4-hydroxypiperidine

: 3-[2-(4-chloro-phenyl)-1-methyl-5-vinyl-1H-indol-3-yl]-propionic acid

: 371970-02-4
1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/S0960-894X(01)00182-2

Reference yield:

: 351227-01-5
methyl 5-bromo-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoate

: 371970-02-4
1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / LiCl; Pd(PPh₃)4 / toluene / 16 h / Heating

2: aq. LiOH / methanol

3: HOBt; Et₃N; EDC / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium chloride; In tetrahydrofuran; methanol; toluene; 1: Stille coupling;
DOI:10.1016/S0960-894X(01)00182-2

Reference yield:

: 371969-25-4
methyl 2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indole-3-propanoate

: 371970-02-4
1-{3-[2-(4-chlorophenyl)-5-ethenyl-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(phenylmethyl)-4-piperidinol

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / methanol

2: HOBt; Et₃N; EDC / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(01)00182-2