5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

Base Information

Chemical Name:5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether
CAS No.:213206-77-0
Molecular Formula:C₁₇H₁₈FNO₅S
Molecular Weight:367.398
Hs Code.:

Synonyms:5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

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Chemical Property of 5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

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Technology Process of 5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

There total 4 articles about 5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4991-65-5
tioxolone

: 213206-77-0
5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 3.5 h / Ambient temperature

2: aq. KOH / methanol / 0.17 h / Ambient temperature

3: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT

4: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h

With potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350332

Reference yield:

: 205186-92-1
6-isopropoxy-1,3-benzoxathiol-2-one

: 213206-77-0
5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: aq. KOH / methanol / 0.17 h / Ambient temperature

2: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT

3: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h

With potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride; In methanol;
DOI:10.1002/jhet.5570350332

Reference yield:

: 205187-15-1
5-isopropoxy-2-mercaptophenol

: 213206-77-0
5-isopropoxy-2-[(methoxymethyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT

2: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h

With 18-crown-6 ether; potassium tert-butylate; sodium hydride;
DOI:10.1002/jhet.5570350332