2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester

Base Information

• Chemical Name: 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester
• CAS No.: 158835-81-5
• Molecular Formula: C₂₂H₂₉N₃O₆
• Molecular Weight: 431.489
• Mol file: 158835-81-5.mol

Synonyms:2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester

Chemical Property of 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester

There total 4 articles about 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-[2-(3,4-dimethoxyphenyl)ethyl]-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester (184001-44-3) → 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester (158835-81-5)

Guidance literature:

With triethylamine; Methanesulfonyl azide; In acetonitrile; for 3h; Ambient temperature;

DOI:10.1021/jo9607267

Reference yield:

5-methylhex-5-enoic acid (55170-74-6) → 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester (158835-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, room temp., 2 h, 2.) CH₂Cl₂, 25 deg C, 10 h

2: 86 percent / benzene / 1 h / Heating

3: 97 percent / mesyl azide, Et₃N / acetonitrile / 3 h / Ambient temperature

With triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In acetonitrile; benzene;

DOI:10.1021/jo9607267

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 2-diazo-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester (158835-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, room temp., 2 h, 2.) CH₂Cl₂, 25 deg C, 10 h

2: 86 percent / benzene / 1 h / Heating

3: 97 percent / mesyl azide, Et₃N / acetonitrile / 3 h / Ambient temperature

With triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In acetonitrile; benzene;

DOI:10.1021/jo9607267

upstream raw materials:

N-[2-(3,4-dimethoxyphenyl)ethyl]-N-(5-methylhex-5-enoyl)malonamic acid ethyl ester

5-methylhex-5-enoic acid

2-(3,4-dimethoxyphenyl)-ethylamine

5-methyl-hex-5-enoic acid [2-(3,4-dimethoxyphenyl)ethyl]amide