naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide

Base Information

• Chemical Name: naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide
• CAS No.: 1185404-75-4
• Molecular Formula: C₂₄H₁₇ClN₂O₂
• Molecular Weight: 400.864
• Mol file: 1185404-75-4.mol

Synonyms:naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide

Chemical Property of naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide

There total 4 articles about naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-N-(2-chloro-phenyl)-benzamide (115175-20-7) + naphthalene-1-carbonic acid chloride (879-18-5) → naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide (1185404-75-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform;

Reference yield:

[3-(2-chloro-phenylcarbamoyl)-phenyl]-carbamic acid tert-butyl ester (1185405-18-8) → naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide (1185404-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0.75 h

2: N-ethyl-N,N-diisopropylamine / chloroform

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In chloroform;

Reference yield:

o-chloroaniline (95-51-2) → naphthalene-1-carboxylic acid [3-(2-chloro-phenylcarbamoyl)-phenyl]-amide (1185404-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / Reflux

2: trifluoroacetic acid / 0.75 h

3: N-ethyl-N,N-diisopropylamine / chloroform

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

upstream raw materials:

3-amino-N-(2-chloro-phenyl)-benzamide

naphthalene-1-carbonic acid chloride

[3-(2-chloro-phenylcarbamoyl)-phenyl]-carbamic acid tert-butyl ester

3-[(tert-butoxycarbonyl)amino]benzoic acid