Technology Process of Z-Phe-D-Pro-Phe-Ala-Glu(OtBu)-Phe-OMe
There total 7 articles about Z-Phe-D-Pro-Phe-Ala-Glu(OtBu)-Phe-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NMM / tetrahydrofuran / 1 h / -10 - 20 °C
2: H2 / 10percent Pd/C / methanol
3: N,N-dimethyl-acetamide
4: H2 / 10percent Pd/C / methanol
5: 1.) 36percent aq. HCl, isopentyl nitrite, 2.) DIPEA / 1.) DMA, -10 deg C, 1.5 h, 2.) DMA, 4 deg C, 12 h
With
4-methyl-morpholine; hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide;
DOI:10.1021/ja00020a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N,N-dimethyl-acetamide
2: H2 / 10percent Pd/C / methanol
3: 1.) 36percent aq. HCl, isopentyl nitrite, 2.) DIPEA / 1.) DMA, -10 deg C, 1.5 h, 2.) DMA, 4 deg C, 12 h
With
hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; isopentyl nitrite;
palladium on activated charcoal;
In
methanol; N,N-dimethyl acetamide;
DOI:10.1021/ja00020a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / 10percent Pd/C / methanol
2: N,N-dimethyl-acetamide
3: H2 / 10percent Pd/C / methanol
4: 1.) 36percent aq. HCl, isopentyl nitrite, 2.) DIPEA / 1.) DMA, -10 deg C, 1.5 h, 2.) DMA, 4 deg C, 12 h
With
hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; isopentyl nitrite;
palladium on activated charcoal;
In
methanol; N,N-dimethyl acetamide;
DOI:10.1021/ja00020a016
