cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

Base Information

Chemical Name:cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide
CAS No.:681828-43-3
Molecular Formula:C₂₂H₂₀N₂O₂S
Molecular Weight:376.479
Hs Code.:

Synonyms:cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

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Chemical Property of cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

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Technology Process of cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

There total 5 articles about cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 681828-44-4
N-phenyl-N-1,2,3,4-tetrahydroquinolin-4-ylacetamide

: 681828-43-3
cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 611-35-8
4-chloroquinoline

: 681828-43-3
cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 0.5 h / 150 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 120 h / Heating / reflux

3: sodium tetrahydroborate; nickel dichloride / methanol / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; nickel dichloride; In 1,4-dioxane; methanol;

Reference yield:

: 681828-29-5
N-phenyl-N-quinolin-4-yl-acetamide

: 681828-43-3
cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel dichloride / methanol / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; nickel dichloride; In 1,4-dioxane; methanol;