N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

Base Information

Chemical Name:N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea
CAS No.:1345017-82-4
Molecular Formula:C₂₁H₁₅F₃N₈O
Molecular Weight:452.398
Hs Code.:

Synonyms:N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

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Chemical Property of N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

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Technology Process of N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

There total 6 articles about N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1289637-33-7
8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

: 103-71-9
phenyl isocyanate

: 1345017-82-4
N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmc.2011.08.026

Reference yield:

: C₁₄H₁₁F₃N₆

: 1345017-82-4
N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: [bis(acetoxy)iodo]benzene

2.1: hydrogenchloride / water / Reflux

2.3: 160 °C

3.1: toluene / Reflux

With hydrogenchloride; [bis(acetoxy)iodo]benzene; In water; toluene;
DOI:10.1016/j.bmc.2011.08.026

Reference yield:

: 159979-75-6
4-cyano-3-[(ethoxymethylene)amino]-1-methylpyrazole

: 1345017-82-4
N-(8-methyl-2-(4-trifluoromethylphenyl)-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-N'-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine

2.1: triethylamine

3.1: [bis(acetoxy)iodo]benzene

4.1: hydrogenchloride / water / Reflux

4.3: 160 °C

5.1: toluene / Reflux

With hydrogenchloride; [bis(acetoxy)iodo]benzene; triethylamine; hydrazine; In water; toluene;
DOI:10.1016/j.bmc.2011.08.026