(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Base Information

Chemical Name:(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene
CAS No.:1431137-71-1
Molecular Formula:C₂₉H₃₈OSi₂
Molecular Weight:458.791
Hs Code.:

Synonyms:(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Suppliers and Price of (5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

There total 10 articles about (5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1431137-70-0
(1S,2R,5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexanol

: 1431137-71-1
(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1431137-66-4
(2R,4R,5R)-2-[(tert-butyldiphenylsilyl)oxy]-5-methyl-4-pivaloyloxy-cyclohexanone

: 1431137-71-1
(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / 0 °C

1.2: 5 h / -78 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - 40 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.75 h / -78 - 0 °C

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;

Reference yield:

: 1431137-68-6
(1R,2R,5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-cyclohexanol

: 1431137-71-1
(5R)-5-[(tert-butyldiphenylsilyl)oxy]-2-methyl-4-methylene-1-[(trimethylsilanyl)ethynyl]-cyclohexene

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.75 h / -78 - 0 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With n-butyllithium; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;