2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Base Information

Chemical Name:2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid
CAS No.:1374748-88-5
Molecular Formula:C₁₆H₉BrF₂N₂O₄
Molecular Weight:411.159
Hs Code.:

Synonyms:2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

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Chemical Property of 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

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Technology Process of 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

There total 3 articles about 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1374748-62-5
methyl 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate

: 1374748-88-5
2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: methyl 2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1002/cmdc.201200054

Reference yield:

: 76089-04-8
2,3-dichloro-6-fluoroquinoxaline

: 1374748-88-5
2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 65 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C

2.2: 0.5 h / 55 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200054

Reference yield:

: 2105-94-4
4-bromo-2-fluorophenol

: 1374748-36-3
3-chloro-6-fluoroquinoxalin-2(1H)-one

: 1374748-88-5
2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C

1.2: 0.5 h / 55 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200054