N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester

Base Information

Chemical Name:N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester
CAS No.:1451156-26-5
Molecular Formula:C₂₈H₂₆N₂O₃
Molecular Weight:438.526
Hs Code.:

Synonyms:N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester

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Chemical Property of N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester

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Technology Process of N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester

There total 1 articles about N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1451156-26-5
N-(4-pentenoyl)-4[(4’;1’,1”)biphenyl]-L-phenylalanine cyanomethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; toluene; water / 15 h / 80 - 85 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 23 h / Inert atmosphere

4: sodium carbonate / water; 1,4-dioxane / 5 h / 20 °C

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 9 h / 20 °C

6: triethylamine / acetonitrile / 40 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/ja403007r