N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Base Information

• Chemical Name: N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)
• CAS No.: 253586-13-9
• Molecular Formula: C₅₂H₇₂N₇O₉PSi
• Molecular Weight: 998.244

Synonyms:N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property of N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

There total 11 articles about N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-acetyl-5'-O-(4,4'-dimethoxytrityl)adenosine (231957-26-9) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (253586-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iPr₂NEt; Bu₂SnCl₂ / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 40 percent / CH₂Cl₂ / 0.33 h / 80 °C

2.1: 93 percent / iPr₂NEt / CH₂Cl₂ / 14 h / 20 °C

With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

Reference yield:

chloromethoxy-triisopropyl-silane (217300-17-9) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (253586-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iPr₂NEt; Bu₂SnCl₂ / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 40 percent / CH₂Cl₂ / 0.33 h / 80 °C

2.1: 93 percent / iPr₂NEt / CH₂Cl₂ / 14 h / 20 °C

With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

Reference yield:

triisopropylsilyl (ethylthio)methyl ether (253586-28-6) → N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (253586-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / SO₂Cl₂ / CH₂Cl₂ / 1 h / 4 - 20 °C

2.1: iPr₂NEt; Bu₂SnCl₂ / 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 40 percent / CH₂Cl₂ / 0.33 h / 80 °C

3.1: 93 percent / iPr₂NEt / CH₂Cl₂ / 14 h / 20 °C

With sulfuryl dichloride; dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/1522-2675(20011219)84:12<3773::AID-HLCA3773>3.0.CO;2-E

upstream raw materials:

O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine

triisopropylsilyl chloride

4,4'-dimethoxytrityl chloride

N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)adenosine

Downstream raw materials:

C₅₀H₇₀N₇O₈PSi

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253586-13-9 N⁶-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Send

Send

Metric Ton KG G Pound L ML

Send

Send