C₃₇H₄₉F₃N₁₀O₁₁S₂

Base Information

• Chemical Name: C₃₇H₄₉F₃N₁₀O₁₁S₂
• CAS No.: 943601-30-7
• Molecular Formula: C₃₇H₄₉F₃N₁₀O₁₁S₂
• Molecular Weight: 930.984
• Mol file: 943601-30-7.mol

Synonyms:C₃₇H₄₉F₃N₁₀O₁₁S₂

Chemical Property of C₃₇H₄₉F₃N₁₀O₁₁S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₉F₃N₁₀O₁₁S₂

There total 16 articles about C₃₇H₄₉F₃N₁₀O₁₁S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H35F3N8O9S + biotin pentafluorophenyl ester (120550-35-8) → C37H49F3N10O11S2 (943601-30-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/ol070376i

Reference yield:

C18H32O7SiSN2 (943601-22-7) → C37H49F3N10O11S2 (943601-30-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 69 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

3.1: 3.15 g / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 1 h / 80 °C

4.1: triphenylphosphine / tetrahydrofuran; H₂O / 1 h / 20 °C

4.2: 53 percent / sodium carbonate / tetrahydrofuran; H₂O / 1 h / 20 °C

5.1: 980 mg / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.17 h / 20 °C

6.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 °C

7.1: 1.09 g / triethylamine / dimethylformamide / 2 h / 20 °C

With sodium azide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: Mitsunobu reaction;

DOI:10.1021/ol070376i

Reference yield:

(2-[2-azidoethoxy]ethyl)-N-nosylethanamine (943601-24-9) → C37H49F3N10O11S2 (943601-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran; H₂O / 1 h / 20 °C

1.2: 53 percent / sodium carbonate / tetrahydrofuran; H₂O / 1 h / 20 °C

2.1: 980 mg / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0.17 h / 20 °C

3.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 °C

4.1: 1.09 g / triethylamine / dimethylformamide / 2 h / 20 °C

With triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: Mitsunobu reaction;

DOI:10.1021/ol070376i

upstream raw materials:

biotin pentafluorophenyl ester

C₁₈H₃₂O₇SiSN₂

N-(2-[2-{2-hydroxyethoxy}ethoxy]ethyl)-2-nitro-benzenesulfonamide

(2-[2-azidoethoxy]ethyl)-N-nosylethanamine

Downstream raw materials:

C₃₁H₄₆F₃N₉O₇S