C₃₅H₄₆O₁₃

Base Information

• Chemical Name: C₃₅H₄₆O₁₃
• CAS No.: 1018988-53-8
• Molecular Formula: C₃₅H₄₆O₁₃
• Molecular Weight: 674.742
• Mol file: 1018988-53-8.mol

Synonyms:C₃₅H₄₆O₁₃

Chemical Property of C₃₅H₄₆O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₄₆O₁₃

There total 20 articles about C₃₅H₄₆O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C35H48O13 (1018988-65-2) → C35H46O13 (1018988-53-8)

Guidance literature:

C₃₅H₄₈O₁₃; With di(n-butyl)tin oxide; In benzene; for 16h; Heating;

With N-Bromosuccinimide; 4 A molecular sieve; In chloroform; at 20 ℃; for 0.166667h; Further stages.;

DOI:10.1002/anie.200704959

Reference yield: 68.0%

C37H46O13 (1018988-52-7) → C35H46O13 (1018988-53-8)

Guidance literature:

C₃₇H₄₆O₁₃; With ozone; In dichloromethane; at -78 ℃; for 2h;

With triphenylphosphine; In dichloromethane; at 20 ℃; for 15h;

With potassium hydrogencarbonate; In methanol; dichloromethane; water; at 20 ℃; for 3h; Further stages.;

DOI:10.1002/anie.200704959

Reference yield:

C52H66O7Si2 (1018988-59-4) → C35H46O13 (1018988-53-8)

Guidance literature:

Multi-step reaction with 19 steps

1.1: sodium tetrahydroborate / ethanol / 2 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 39 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: 2,6-di-tert-butyl-4-methylpyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / -40 - -30 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 13 °C / Inert atmosphere

7.1: lithium borohydride / tetrahydrofuran / Inert atmosphere; Reflux

7.2: 4 h / 20 °C / Inert atmosphere

8.1: lithium borohydride / tetrahydrofuran / 26.5 h / 20 °C / Inert atmosphere; Reflux

8.2: 4 h / 20 °C / Inert atmosphere

9.1: water; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

10.1: dmap / pyridine; dichloromethane / 24 h / 20 °C / Inert atmosphere

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

12.1: peracetic acid; mercury(II) diacetate; acetic acid / 4 h / 20 °C / Inert atmosphere

13.1: 1H-imidazole / dichloromethane / 4 h / 0 °C / Inert atmosphere

14.1: dmap / pyridine; dichloromethane / 0 - 40 °C / Inert atmosphere

15.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

16.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

17.1: Wilkinson's catalyst; triphenylphosphine; isopropyl alcohol / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

18.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 5 h / 20 °C / Inert atmosphere

19.1: di(n-butyl)tin oxide / benzene / 16 h / Reflux; Inert atmosphere

19.2: 0.17 h / 20 °C / Inert atmosphere; Molecular sieve

With 1H-imidazole; peracetic acid; dmap; sodium tetrahydroborate; Wilkinson's catalyst; osmium(VIII) oxide; lithium borohydride; 2,6-di-tert-butyl-4-methylpyridine; mercury(II) diacetate; tetrabutyl ammonium fluoride; water; di(n-butyl)tin oxide; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; isopropyl alcohol; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; acetone; acetonitrile; benzene; 5.1: Luche reduction / 12.1: Tamao oxidation;

DOI:10.1002/asia.200800429

upstream raw materials:

C₃₇H₄₆O₁₃

C₃₅H₄₈O₁₃

C₅₂H₆₆O₇Si₂

C₅₂H₆₈O₇Si₂

Downstream raw materials:

C₃₅H₄₈O₁₃

C₃₇H₄₆O₁₃

C₅₀H₆₄O₁₂Si

C₃₄H₄₄O₁₂

Refernces

• 1、 Zhang, Hongxing,Sridhar Reddy, Maddi,Phoenix, Serge,Deslongchamps, Pierre. "Total synthesis of ouabagenin and ouabain". . p. 1272 - 1275. Retrieved 2008/12/22.