2,2'-Dichloro-4,4'-bipyridine

Base Information

• Chemical Name: 2,2'-Dichloro-4,4'-bipyridine
• CAS No.: 53344-74-4
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.077
• Hs Code.: 2933399090
• European Community (EC) Number: 678-889-5
• DSSTox Substance ID: DTXSID20409132
• Nikkaji Number: J3.250.049H
• Wikidata: Q72465698
• Mol file: 53344-74-4.mol

Synonyms:2,2'-dichloro-4,4'-bipyridine;53344-74-4;2-chloro-4-(2-chloropyridin-4-yl)pyridine;2,2'-Dichloro-4,4'bipyridine;2,2'-DICHLORO-[4,4']-BIPYRIDINE;4,4'-Bipyridine, 2,2'-dichloro-;SCHEMBL4027001;DTXSID20409132;KSELKNWXBOXHEV-UHFFFAOYSA-N;MFCD01106345;2,2'-dichloro-[4,4']-bipyridinyl;AKOS015991259;BS-2081;CS-0315861;FT-0647368;A870749;J-400161

Chemical Property of 2,2'-Dichloro-4,4'-bipyridine

Chemical Property:

• Melting Point: 240-243℃
• Boiling Point: 347.395 °C at 760 mmHg
• Flash Point: 194.754 °C
• PSA: 25.78000
• Density: 1.364 g/cm³
• LogP: 3.45040
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.9908036
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

97% ^*data from raw suppliers

2,2'-Dichloro-[4,4']bipyridine 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=C(C=C1C2=CC(=NC=C2)Cl)Cl

Technology Process of 2,2'-Dichloro-4,4'-bipyridine

There total 5 articles about 2,2'-Dichloro-4,4'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloro-4-iodopyridine (153034-86-7) + (p-chlorophenyl)triethoxysilane (21700-74-3) → 2-chloro-4-(4-chlorophenyl)pyridine (883874-86-0) + 2,2′-dichloro-4,4′-bipyridinyl (53344-74-4)

Guidance literature:

With copper(l) iodide; cesium fluoride; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol402701x

Reference yield: 73.0%

2-chloro-4-iodopyridine (153034-86-7) + triethoxy(thiophen-2-yl)silane (17984-89-3) → 2-chloro-4-(thiophen-2-yl)pyridine (1289555-51-6) + 2,2′-dichloro-4,4′-bipyridinyl (53344-74-4)

Guidance literature:

With copper(l) iodide; cesium fluoride; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol402701x

Reference yield: 70.0%

2-chloro-4-iodopyridine (153034-86-7) + p-tolyltriethoxysilane (18412-57-2) → 2-chloro-4-(4-methylphenyl)pyridine (1202574-24-0) + 2,2′-dichloro-4,4′-bipyridinyl (53344-74-4)

Guidance literature:

With copper(l) iodide; cesium fluoride; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol402701x

upstream raw materials:

2-chloro-4-iodopyridine

4-trifluoromethylphenyltriethoxysilane

triethoxyphenylsilane

(p-chlorophenyl)triethoxysilane

Downstream raw materials:

4,4'-bis(3,3'-dicyano)pyridine

N,N'-bis(3,4-difluorophenyl)-4,4'-bipyridine-2,2'-diamine

2,2'-dimethoxy-4,4'-bipyridine