3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide

Base Information

• Chemical Name: 3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide
• CAS No.: 144686-21-5
• Molecular Formula: C₂₄H₃₁N₃O₄S
• Molecular Weight: 457.594

Synonyms:3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide

Chemical Property of 3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide

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Technology Process of 3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide

There total 1 articles about 3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2,5,5-tetramethyl-2,5-dihydro-thiazole (13206-47-8) + Cyclohexyl isocyanide (931-53-3) + N-phthaloylglycine (4702-13-0) → 3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide (144686-21-5)

Guidance literature:

In methanol; at 0 - 15 ℃; other 2,5-dihydro-1,3-thiazole, other isocyanide and other N-phthaloylamino acid;

DOI:10.1055/s-1992-26240

Reference yield: 69.0%

3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide (144686-21-5) → 3-(2-Amino-acetyl)-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide (144686-16-8)

Guidance literature:

With hydrazine hydrate; In methanol; at 50 ℃; for 12h;

DOI:10.1055/s-1992-26240

upstream raw materials:

2,2,5,5-tetramethyl-2,5-dihydro-thiazole

Cyclohexyl isocyanide

N-phthaloylglycine

Downstream raw materials:

3-(2-Amino-acetyl)-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid cyclohexylamide

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