(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

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Chemical Name:(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid
CAS No.:164713-49-9
Molecular Formula:C₁₉H₁₇NO₄S
Molecular Weight:355.414
Hs Code.:

Synonyms:(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

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Chemical Property of (1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

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Technology Process of (1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

There total 4 articles about (1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 858101-79-8
(+)-(1S,2S)-tert-butyl 2-(1-tosyl-1H-indol-3-yl)cyclopropane-1-carboxylate

: 164713-49-9
(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol050790n

Reference yield: 80.0%

: (+)-N-<(1S,2S)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cycloprop-1-ylcarbonyl>bornane-10,2-sultam

: 164713-49-9
(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/jo00116a028

Reference yield:

: 50562-79-3
1-(4-tolylsulfonyl)indole-3-carboxaldehyde

: 164713-49-9
(1S,2S)-(+)-trans-2-<1-(p-Toluenesulfonyl)indol-3-yl>cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -15 - -5 °C

2: (S)-trans-Cl₂Ru(pybox-ip)(CH₂=CH₂) / toluene / 16 h / 50 °C

3: 100 percent / CF₃COOH / CH₂Cl₂ / 12 h / 20 °C

With n-butyllithium; trifluoroacetic acid; (S)-trans-Cl₂Ru(pybox-ip)(CH₂=CH₂); In tetrahydrofuran; hexane; dichloromethane; toluene; 1: Wittig methylenation;
DOI:10.1021/ol050790n