2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

Base Information

Chemical Name:2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid
CAS No.:1430231-80-3
Molecular Formula:C₂₇H₂₆O₅
Molecular Weight:430.5
Hs Code.:

Synonyms:2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

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Chemical Property of 2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

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Technology Process of 2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

There total 11 articles about 2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: 2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid methyl ester

: 1430231-80-3
2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 2-((3S)-6-(1-(3-bromophenyl)-2-(tert-butyldimethylsilyloxy)ethoxy)-5-iodo-2,3-dihydrobenzofuran-3-yl)acetic acid methyl ester

: 1430231-80-3
2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere

2: palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate / toluene / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran; methanol / 0.5 h / 50 °C / Inert atmosphere

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; palladium diacetate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;

Reference yield:

: 1430232-70-4
(S)-2-(6-hydroxy-5-iodo-2,3-dihydrobenzofuran-3-yl)acetic acid methyl ester

: 1430231-80-3
2-((8S)-3-(2,’4’6’-trimethyl[1,1’-biphenyl]-3-yl)-2,3,7,8-tetrahydrobenzofuran[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-azodicarbonyl-dipiperidine; tri-tert-butyl phosphine / toluene / 12 h / 50 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere

3: palladium diacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; caesium carbonate / toluene / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

4: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran; methanol / 0.5 h / 50 °C / Inert atmosphere

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; palladium diacetate; caesium carbonate; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;