p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne

Base Information

• Chemical Name: p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne
• CAS No.: 117570-30-6
• Molecular Formula: C₂₃H₂₆FNO₅S
• Molecular Weight: 447.528
• Mol file: 117570-30-6.mol

Synonyms:p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne

Chemical Property of p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne

There total 3 articles about p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hydroxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne (108275-37-2,117569-97-8,117570-19-1) + p-toluenesulfonyl chloride (98-59-9) → p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne (117570-30-6)

Guidance literature:

In tetrahydrofuran; pyridine; at 40 ℃; for 48h;

DOI:10.1016/S0040-4020(01)85897-X

Reference yield:

oxo-4 fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne → p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne (117570-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: 90 percent / pyridine; tetrahydrofuran / 48 h / 40 °C

With sodium tetrahydroborate; In tetrahydrofuran; pyridine; methanol;

DOI:10.1016/S0040-4020(01)85897-X

Reference yield:

<(methoxymethyleneoxy-2' fluoro-3' phenyl)-1 epoxy-2,3β cyclohexyl-1>-2 N,N-dimethylacetamide → p.toluenesulfonyloxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne (117570-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / CH₂Cl₂ / 10 h / Heating

2: 90 percent / pyridine; tetrahydrofuran / 48 h / 40 °C

In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1016/S0040-4020(01)85897-X

upstream raw materials:

hydroxy-4β fluoro-6 N,N-dimethylcarboxamidomethyl-9bβ hexahydrodibenzofuranne

p-toluenesulfonyl chloride