(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

Base Information

Chemical Name:(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine
CAS No.:1289626-34-1
Molecular Formula:C₁₀H₁₅NO*C₁₂H₁₅BrO₄S
Molecular Weight:500.454
Hs Code.:

Synonyms:(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

Chemical Property:

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Technology Process of (2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

There total 4 articles about (2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1289626-08-9
4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 1289626-34-1
(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

Guidance literature:: In water; isopropyl alcohol; Heating;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1289626-34-1
(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 1 h / 0 - 25 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 0 - 25 °C

3.2: pH 4

4.1: isopropyl alcohol; water / Heating

With 1H-imidazole; water; iodine; caesium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 85356-68-9
1-bromo-4-(2-iodoethyl)benzene

: 1289626-34-1
(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 0 - 25 °C

2.2: pH 4

3.1: isopropyl alcohol; water / Heating

With water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;