3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane
• CAS No.: 1224513-60-3
• Molecular Formula: C₁₅H₂₁N₅O₄
• Molecular Weight: 335.363
• Mol file: 1224513-60-3.mol

Synonyms:3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane

Chemical Property of 3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

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Technology Process of 3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane

There total 1 articles about 3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

N-[(methoxycarbonyl)methyl]-(S)-p-nitrophenylalanine methyl ester (189804-82-8) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → 3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane (1224513-60-3)

Guidance literature:

In methanol; for 264h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.048

Reference yield: 28.0%

3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane (1224513-60-3) → 2-(S)-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane trihydrochloride

Guidance literature:

3-(S)-(4-nitrobenzyl)-2,6-dioxo-1,4,7,10-tetraazacyclododecane; With borane-THF; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; for 16h; Reflux;

DOI:10.1016/j.bmc.2010.01.048

upstream raw materials:

N-[(methoxycarbonyl)methyl]-(S)-p-nitrophenylalanine methyl ester

3-azapentane-1,5-diamine