(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline

Base Information

• Chemical Name: (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline
• CAS No.: 1239950-19-6
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.397

Synonyms:(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline

Chemical Property of (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline

Chemical Property:

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Technology Process of (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline

There total 7 articles about (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1S)-6,7-dimethoxy-3-oxo-1-phenethyl-1,2,3,4-tetrahydroisoquinoline (1242161-99-4) → (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline (1239950-19-6)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1002/ejoc.201000473

Reference yield: 63.0%

(1S,4R)-1-<(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (123279-32-3) → (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline (1239950-19-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1002/ardp.19903230605

Reference yield:

(1S,4R)-1-<1,2,3,4-Tetrahydro-6,7-dimethoxy-1-<2-(4-Chlorophenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (123279-30-1,123355-79-3) → (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-isoquinoline (1239950-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C (10percent Pd) / acetic acid; trifluoroacetic acid / 44 h / 2250.2 Torr / Ambient temperature

2: 63 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

With lithium aluminium tetrahydride; hydrogen; 10% palladium on active carbon; In tetrahydrofuran; acetic acid; trifluoroacetic acid;

DOI:10.1002/ardp.19903230605

upstream raw materials:

(1S,4R)-1-<(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

(1S,4R)-1-<1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(2-oxo-2-phenyl-1-ethyl)-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

(1S,4R)-1-<1,2,3,4-Tetrahydro-6,7-dimethoxy-1-<2-(4-Chlorophenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

(1S)-6,7-dimethoxy-3-oxo-1-phenethyl-1,2,3,4-tetrahydroisoquinoline

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