4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

Base Information

Chemical Name:4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane
CAS No.:1199791-35-9
Molecular Formula:C₃₆H₄₁Cl₂N₅O₃S
Molecular Weight:694.725
Hs Code.:

4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

Synonyms:4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

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Chemical Property of 4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

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Technology Process of 4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

There total 11 articles about 4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1199791-32-6
7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

: 108-24-7
acetic anhydride

: 1199791-35-9
4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: In pyridine; at 20 ℃; for 4h;

Reference yield:

: 1033714-55-4
1-benzyl 2-tert-butyl (2S,5R)-5-methylpyrrolidine-1,2-dicarboxylate

: 1199791-35-9
4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

2.1: thionyl chloride / toluene / 1.5 h / 70 °C

2.2: 16 h / 20 °C

3.1: methoxybenzene; trifluoroacetic acid / chloroform / 2 h / 20 - 40 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: pyridine / 4 h / 20 °C

With thionyl chloride; hydrogen; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In pyridine; methanol; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1033713-89-1
1-benzyl 2-tert-butyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate

: 1199791-35-9
4-acetyl-7-[(2S,5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-methyl-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: Multi-step reaction with 6 steps

1.1: methyllithium; trifluoroborane diethyl ether / copper(I) bromide dimethylsulfide complex / diethyl ether / 20 °C

1.2: 0.5 h

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: thionyl chloride / toluene / 1.5 h / 70 °C

3.2: 16 h / 20 °C

4.1: methoxybenzene; trifluoroacetic acid / chloroform / 2 h / 20 - 40 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: pyridine / 4 h / 20 °C

With thionyl chloride; methyllithium; hydrogen; trifluoroborane diethyl ether; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; In pyridine; methanol; diethyl ether; chloroform; N,N-dimethyl-formamide; toluene;