diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate

Base Information

Chemical Name:diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate
CAS No.:127322-57-0
Molecular Formula:C₃₆H₄₅N₅O₉
Molecular Weight:691.781
Hs Code.:

Synonyms:diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate

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Chemical Property of diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate

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Technology Process of diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate

There total 4 articles about diethyl N-[4-{1-(tetrahydropyr-2-yloxy)-3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)prop-2-en-2-yl}benzoyl]glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 127322-57-0
2-{4-[(Z)-2-[2-(2,2-Dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-1-(tetrahydro-pyran-2-yloxymethyl)-vinyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PdCl₂

2: H₂ / Pd/BaSO₄, quinoline

3: Pd(OAc)2

With hydrogen; quinoline; palladium diacetate; Pd-BaSO₄; palladium dichloride;
DOI:10.1002/jhet.5570270101

Reference yield:

: 116387-22-5
2-pivaloylamino-6-bromo-4(3H)-pyrido[2,3-d]pyrimidinone

: 127322-57-0
2-{4-[(Z)-2-[2-(2,2-Dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-1-(tetrahydro-pyran-2-yloxymethyl)-vinyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PdCl₂

2: H₂ / Pd/BaSO₄, quinoline

3: Pd(OAc)2

With hydrogen; quinoline; palladium diacetate; Pd-BaSO₄; palladium dichloride;
DOI:10.1002/jhet.5570270101

Reference yield:

: 127322-55-8
2-(Pivaloylamino)-6-<3-(tetrahydropyranyl-2'-oxy)prop-1-ynyl>-4(3H)-oxopyrido<2,3-d>pyrimidine

: 127322-57-0
2-{4-[(Z)-2-[2-(2,2-Dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-1-(tetrahydro-pyran-2-yloxymethyl)-vinyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/BaSO₄, quinoline

2: Pd(OAc)2

With hydrogen; quinoline; palladium diacetate; Pd-BaSO₄;
DOI:10.1002/jhet.5570270101