3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea

Base Information

Chemical Name:3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea
CAS No.:25546-09-2
Molecular Formula:C9H11ClN2O2
Molecular Weight:214.652
Hs Code.:2924299090
European Community (EC) Number:247-089-4
UNII:5MR8SJ354D
DSSTox Substance ID:DTXSID40180239
Nikkaji Number:J287.278A
Wikidata:Q83050777
Mol file:25546-09-2.mol

Synonyms:3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea;25546-09-2;EINECS 247-089-4;5MR8SJ354D;N'-(4-Chloro-2-hydroxyphenyl)-N,N-dimethylurea;Urea, N'-(4-chloro-2-hydroxyphenyl)-N,N-dimethyl-;UNII-5MR8SJ354D;Urea,N'-(4-chloro-2-hydroxyphenyl)-N,N-dimethyl-;SCHEMBL11135310;DTXSID40180239;1-(4-CHLORO-2-HYDROXYPHENYL)-3,3-DIMETHYLUREA

Suppliers and Price of 3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea

Chemical Property:

Vapor Pressure:1.25E-06mmHg at 25°C
Refractive Index:1.628
Boiling Point:389.7 °C at 760 mmHg
Flash Point:189.5 °C
PSA：56.06000
Density:1.37 g/cm³
LogP:2.15270
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:214.0509053
Heavy Atom Count:14
Complexity:211

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C(=O)NC1=C(C=C(C=C1)Cl)O

Technology Process of 3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea

There total 8 articles about 3-(4-Chloro-2-hydroxyphenyl)-1,1-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 905303-89-1
4-chloro-2-hydroxy-benzoyl azide

: 25546-09-2
N¹N¹-dimethyl-N²-(2-hydroxy-4-chlorophenyl) urea

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / diethyl ether / 20 °C

2: toluene / 60 - 90 °C

3: 0 °C

4: KOH

With potassium hydroxide; triethylamine; In diethyl ether; toluene; 2: Curtius rearrangement;
DOI:10.1021/jf060351i

Reference yield:

: 905303-90-4
acetic acid 2-azidocarbonyl-5-chloro-phenyl ester

: 25546-09-2
N¹N¹-dimethyl-N²-(2-hydroxy-4-chlorophenyl) urea

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 60 - 90 °C

2: 0 °C

3: KOH

With potassium hydroxide; In toluene; 1: Curtius rearrangement;
DOI:10.1021/jf060351i

Reference yield:

: 22717-55-1
methyl 4-chloro-2-hydroxybenzoate

: 25546-09-2
N¹N¹-dimethyl-N²-(2-hydroxy-4-chlorophenyl) urea

Guidance literature:: Multi-step reaction with 6 steps

1: NH₂NH₂ / H₂O / 20 °C

2: NaNO₂; aq. AcOH / 0 °C

3: Et₃N / diethyl ether / 20 °C

4: toluene / 60 - 90 °C

5: 0 °C

6: KOH

With potassium hydroxide; acetic acid; triethylamine; hydrazine; sodium nitrite; In diethyl ether; water; toluene; 4: Curtius rearrangement;
DOI:10.1021/jf060351i