2-(5-Methylpyridin-2-yl)acetonitrile

Base Information

• Chemical Name: 2-(5-Methylpyridin-2-yl)acetonitrile
• CAS No.: 38203-08-6
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Mol file: 38203-08-6.mol

Synonyms:5-methyl-2-pyridineacetonitrile

Chemical Property of 2-(5-Methylpyridin-2-yl)acetonitrile

Chemical Property:

• Vapor Pressure: 0.0183mmHg at 25°C
• Boiling Point: 105-106 °C(Press: 3 Torr)
• PKA: 3.47±0.22(Predicted)
• Density: 1.056±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

≥95% ^*data from raw suppliers

2-(5-Methylpyridin-2-yl)acetonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-Methylpyridin-2-yl)acetonitrile

There total 7 articles about 2-(5-Methylpyridin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Bromo-5-methylpyridine (3510-66-5) → 5-methyl-2-pyridineacetonitrile (38203-08-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; acetonitrile;

Reference yield: 80.0%

2-Bromo-5-methylpyridine (3510-66-5) + acetonitrile (75-05-8,26809-02-9) → 5-methyl-2-pyridineacetonitrile (38203-08-6)

Guidance literature:

acetonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

2-Bromo-5-methylpyridine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Product distribution / selectivity;

Reference yield: 68.0%

→ 5-methyl-2-pyridineacetonitrile (38203-08-6)

Guidance literature:

upstream raw materials:

5-methyl-pyridin-2-ylmethyl chloride

potassium cyanide

2-hydroxymethyl-5-methylpyridine

2-acetoxymethyl-5-methyl pyridine

Downstream raw materials:

N₁-(2-methoxy-4-methylbenzyl)-N₂-(2-(5-methylpyridin-2-yl)ethyl) oxalamide

2,5-dimethylpyridine

ethyl 2-(5-methylpyridin-2-yl)acetate

Refernces

• 1、 Nishigaya, Yosuke,Umei, Kentaro,Yamamoto, Eri,Kohno, Yasushi,Seto, Shigeki. "Direct access to 2-aminopyrazolo[1,5-a]pyridines via N-amination/cyclization reactions of 2-pyridineacetonitriles". supporting information. p. 5963 - 5966. Retrieved 2014/12/11.
• 2、 -. "Comestible compositions comprising high potency savory flavorants, and processes for producing them". Page/Page column 79. . Retrieved 2012/04/10.