BOC-D-DAP(BOC)-OH DCHA

Base Information

• Chemical Name: BOC-D-DAP(BOC)-OH DCHA
• CAS No.: 159652-30-9
• Molecular Formula: C₁₃H₂₄N₂O₆
• Molecular Weight: 304.343
• Mol file: 159652-30-9.mol

Synonyms:(R)-2,3-bis-tert-butoxycarbonylaminopropionic acid

Chemical Property of BOC-D-DAP(BOC)-OH DCHA

Chemical Property:

• Boiling Point: 469.0±40.0 °C(Predicted)
• PKA: 3.69±0.10(Predicted)
• Density: 1.157±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

N-alpha,Nbeta-Di-Boc-D-2,3-diaminopropionic acid dicyclohexylamine salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-D-DAP(BOC)-OH DCHA

There total 6 articles about BOC-D-DAP(BOC)-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

D-DAP (515-94-6,1915-96-4,4033-39-0,6018-54-8) + di-tert-butyl dicarbonate (24424-99-5) → (R)-2,3-bis-tert-butoxycarbonylaminopropionic acid (159652-30-9)

Guidance literature:

With triethylamine;

DOI:10.1039/c2ob27084f

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + (2R)-2,3-diaminopropanoic acid monohydrochloride (1482-97-9,6018-55-9,6018-56-0,19777-68-5,19777-69-6,28843-13-2,54897-59-5,69531-11-9,125767-61-5) → (R)-2,3-bis-tert-butoxycarbonylaminopropionic acid (159652-30-9)

Guidance literature:

(2R)-2,3-diaminopropanoic acid monohydrochloride; With triethylamine; In 1,4-dioxane; water; at 0 - 5 ℃;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 10 - 20 ℃; for 16.5h;

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-2-tert-butoxycarbonyl-3-aminopropionic acid (73259-81-1,113625-76-6,76387-70-7) → (R)-2,3-bis-tert-butoxycarbonylaminopropionic acid (159652-30-9)

Guidance literature:

With triethylamine;

DOI:10.1039/c2ob27084f

upstream raw materials:

t-butyl malonate

(2R)-2,3-diaminopropanoic acid monohydrochloride

N-t-butyloxycarbonyl-D-asparagine

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₃H₄₂N₄O₅

C₂₃H₃₆N₄O₅

{(R)-2-tert-butoxycarbonylamino-2-[1-phenyl-5-(3-propylphenyl)-1H-pyrazol-3-ylcarbamoyl]-ethyl}carbamic acid tert-butyl ester