(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
CAS No.:253882-07-4
Molecular Formula:C₂₇H₃₈N₂O₄
Molecular Weight:454.61
Hs Code.:

Synonyms:(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

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Chemical Property of (+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

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Technology Process of (+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

There total 5 articles about (+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 253882-18-7
(-)-(S)-4-(N,N-dibenzylamino)-5-(triphenylmethoxy)-1-pentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

: 253882-07-4
(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo991095u

Reference yield: 29.0%

: 146176-60-5
2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride

: 142784-66-5
(S)-2-(N,N-dibenzylamino)-1,5-pentanediol

: 951330-00-0
2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylic acid (S)-2-(N,N-dibenzylamino)-5-hydroxypent-1-yl ester

: 253882-07-4
(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; Heating;
DOI:10.1021/jo991095u

Reference yield:

: 205068-04-8
(S)-2-(N,N-dibenzylamino)-5-(tert-butyldimethylsilyloxy)pentan-1-ol

: 253882-07-4
(+)-(S)-4-(N,N-dibenzylamino)-5-hydroxypentyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 36 h / 20 °C

2: 100 percent / TBAF / tetrahydrofuran; diethyl ether / 2 h / 20 °C

3: 87 percent / NaH / tetrahydrofuran / Heating

4: 78 percent / TFA / methanol; CH₂Cl₂ / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Substitution / 2: Substitution / 3: Acylation / 4: Hydrolysis;
DOI:10.1021/jo991095u