{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Base Information

Chemical Name:{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid
CAS No.:1432911-10-8
Molecular Formula:C₂₃H₂₁ClFNO₄S
Molecular Weight:461.941
Hs Code.:

Synonyms:{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

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Chemical Property of {4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Chemical Property:

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Technology Process of {4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

There total 11 articles about {4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432911-16-4
{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

: 1432911-10-8
{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

: 1432911-15-3
[4-(3-tert-butoxycarbonylamino-1-methylene-propyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

: 1432911-10-8
{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / 0 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1227259-08-6
(6-fluoro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester

: 1432911-10-8
{4-[3-(2-chloro-benzenesulfonylamino)-1-methylene-propyl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; palladium diacetate; lithium chloride; zinc / tetrahydrofuran; ethylene dibromide / 3 h / 50 - 63 °C / Inert atmosphere

1.2: 55 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / 0 - 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

With chloro-trimethyl-silane; water; palladium diacetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; zinc; In tetrahydrofuran; dichloromethane; ethylene dibromide;