3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

Base Information

Chemical Name:3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide
CAS No.:1610591-98-4
Molecular Formula:C₂₇H₃₆ClN₅O₃S
Molecular Weight:546.134
Hs Code.:

Synonyms:3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

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Chemical Property of 3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

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Technology Process of 3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

There total 8 articles about 3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1610591-85-9
tert-butyl (6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)carbamate

: 1610591-81-5
3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylic acid

: 1610591-98-4
3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm500457x

Reference yield:

: 75950-19-5
tert-butyl [6-[(methylsulphonyl)oxy]hexyl]carbamate

: 1610591-98-4
3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile / 0.08 h

1.2: 8 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm500457x

Reference yield:

: 1610591-78-0
ethyl 3-(1,3-dioxoisoindolin-2-yl)-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylate

: 1610591-98-4
3-amino-5-chloro-6-methoxy-N-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; hydrogenchloride / water / 1.5 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: sodium hydroxide / ethanol / 1.5 h / Reflux

4: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With hydrogenchloride; N-chloro-succinimide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500457x