3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Base Information

Chemical Name:3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide
CAS No.:1616363-66-6
Molecular Formula:C₂₅H₂₃ClN₆OS
Molecular Weight:491.016
Hs Code.:

Synonyms:3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Chemical Property of 3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Technology Process of 3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

There total 6 articles about 3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616361-50-2
3-chloro-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

: 1616363-66-6
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

: 1616363-67-7
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4S)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: With diethylamine; In methanol; ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 2524-52-9,1228273-66-2
ethyl-2-picolinate

: 1616363-66-6
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

: 1616363-67-7
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4S)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 65 °C

2: ethanol / 18.5 h / 20 - 75 °C

3: acetonitrile / 0.33 h / 150 °C / Microwave irradiation

4: borane-THF / tetrahydrofuran / 2 h / Reflux

5: molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 1 h / 100 °C / Sealed tube; Microwave irradiation

6: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 40 °C

7: diethylamine / methanol; ethanol; n-heptane / Resolution of racemate

With borane-THF; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; lithium hexamethyldisilazane; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; ethanol; n-heptane; acetonitrile; mineral oil;

Reference yield:

: 1616363-68-8
4-(4-bromo-2-chlorophenyl)-1-methyl-3-(2-pyridyl)-4,8-dihydropyrazolo[3,4-e][1,4]thiazepin-7-one

: 1616363-66-6
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4R)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

: 1616363-67-7
3-chloro-N-(2-methyl-3-pyridyl)-4-[(4S)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 2 h / Reflux

2: molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 1 h / 100 °C / Sealed tube; Microwave irradiation

3: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 40 °C

4: diethylamine / methanol; ethanol; n-heptane / Resolution of racemate

With borane-THF; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; lithium hexamethyldisilazane; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; ethanol; n-heptane; acetonitrile;