(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Base Information

Chemical Name:(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester
CAS No.:224578-43-2
Molecular Formula:C₃₂H₅₀O₇Si
Molecular Weight:574.83
Hs Code.:

Synonyms:(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Suppliers and Price of (2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

There total 9 articles about (2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 15082-42-5
lithium benzyloxide

: 224578-27-2
(R)-4-Benzyl-3-[(2R,3S,4S,5R)-7-(4-methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

: 224578-43-2
(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 224578-43-2
(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / Bu₂BOTf, Et₃N / CH₂Cl₂ / -78 °C

2: 84 percent / i-Pr₂NEt

3: 89 percent / LiBH₄ / diethyl ether; H₂O

4: Swern

5: Bu₂BOTf, Et₃N / CH₂Cl₂ / -40 °C

6: 84 percent / imidazole / CH₂Cl₂

7: 89 percent / tetrahydrofuran

With 1H-imidazole; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 224578-43-2
(2R,3S,4S,5R)-7-(4-Methoxy-benzyloxy)-5-methoxymethoxy-2,4-dimethyl-3-triethylsilanyloxy-heptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent

2: 94 percent / Swem oxidation

3: 96 percent / Bu₂BOTf, Et₃N / CH₂Cl₂ / -78 °C

4: 84 percent / i-Pr₂NEt

5: 89 percent / LiBH₄ / diethyl ether; H₂O

6: Swern

7: Bu₂BOTf, Et₃N / CH₂Cl₂ / -40 °C

8: 84 percent / imidazole / CH₂Cl₂

9: 89 percent / tetrahydrofuran

With 1H-imidazole; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(99)00209-9