(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

Base Information

Chemical Name:(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate
CAS No.:1426336-92-6
Molecular Formula:C₂₂H₂₀FN₅O₅
Molecular Weight:453.43
Hs Code.:

Synonyms:(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

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Chemical Property of (S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

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Technology Process of (S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

There total 8 articles about (S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 1426337-34-9
C₁₆H₁₆FN₅O₄

: 1426336-92-6
(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 96h;

Reference yield:

: 1426337-12-3
(S)-methyl 2-chloro-6-((1-methoxy-1-oxopropan-2-yl)amino)pyrimidine-4-carboxylate

: 1426336-92-6
(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 72 h / 50 °C / Sealed tube

2: caesium carbonate; water; bis-triphenylphosphine-palladium(II) chloride / ethanol; 1,2-dimethoxyethane / 3 h / 80 °C / Sealed tube; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 96 h / 65 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonia; water; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1426336-92-6
(S)-methyl 5-(4-((1-amino-1-oxopropan-2-yl)amino)-6-carbamoylpyrimidin-2-yl)-2-(4-fluorophenoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C

2: ammonia / methanol / 72 h / 50 °C / Sealed tube

3: caesium carbonate; water; bis-triphenylphosphine-palladium(II) chloride / ethanol; 1,2-dimethoxyethane / 3 h / 80 °C / Sealed tube; Inert atmosphere

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 96 h / 65 °C

With bis-triphenylphosphine-palladium(II) chloride; ammonia; water; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;