C₁₅H₂₀N₂O₆S

Base Information

• Chemical Name: C₁₅H₂₀N₂O₆S
• CAS No.: 1231765-66-4
• Molecular Formula: C₁₅H₂₀N₂O₆S
• Molecular Weight: 356.4
• Mol file: 1231765-66-4.mol

Synonyms:C₁₅H₂₀N₂O₆S

Chemical Property of C₁₅H₂₀N₂O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₀N₂O₆S

There total 8 articles about C₁₅H₂₀N₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C9H16O3 (1231765-65-3) + 2-Nitrobenzenesulfonamide (5455-59-4) → C15H20N2O6S (1231765-66-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol4005239

Reference yield:

(-)-(1S,6R)-9-oxabicyclo[4.2.1]non-7-en-1-ol (1428423-13-5) → C15H20N2O6S (1231765-66-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium dihydrogenphosphate dihydrate; [hydroxy(tosyloxy)iodo]benzene / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 2 h / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: camphor-10-sulfonic acid / methanol / 1 h / 0 °C / Inert atmosphere

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium dihydrogenphosphate dihydrate; di-isopropyl azodicarboxylate; [hydroxy(tosyloxy)iodo]benzene; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 6.1: |Mitsunobu Displacement;

DOI:10.1021/ol4005239

Reference yield:

C8H14O3 (1231765-74-4) → C15H20N2O6S (1231765-66-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: camphor-10-sulfonic acid / methanol / 1 h / 0 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 4.1: |Mitsunobu Displacement;

DOI:10.1021/ol4005239

upstream raw materials:

C₉H₁₆O₃

2-Nitrobenzenesulfonamide

1,3-cyclooctadiene

9,10-dioxabicyclo<4.2.2>deca-7-ene

Downstream raw materials:

C₂₄H₃₄N₂O₈S