ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate

Base Information

• Chemical Name: ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate
• CAS No.: 113181-04-7
• Molecular Formula: C₃₂H₄₈O₄Se
• Molecular Weight: 575.691
• Mol file: 113181-04-7.mol

Synonyms:ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate

Chemical Property of ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate

There total 2 articles about ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diphenyl diselenide (1666-13-3) + ethyl 3α,7β-dihydroxy-5β-cholan-24-oate (69519-36-4) → ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate (113181-04-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1021/jm00399a007

Reference yield:

ursodeoxycholic acid (128-13-2) → ethyl 3α,7β-dihydroxy-23-(phenylseleno)-5β-cholan-24-oate (113181-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / toluene-4-sulfonic acid / 24 h / Ambient temperature

2: 84 percent / LDA / hexane; tetrahydrofuran / 2 h / -78 °C

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/jm00399a007

upstream raw materials:

diphenyl diselenide

ethyl 3α,7β-dihydroxy-5β-cholan-24-oate

ursodeoxycholic acid

Refernces