4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

Base Information

Chemical Name:4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine
CAS No.:1373425-71-8
Molecular Formula:C₃₁H₄₀N₂O₄SSi
Molecular Weight:564.821
Hs Code.:

Synonyms:4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

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Technology Process of 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

There total 3 articles about 4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1352789-43-5
1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)pent-4-yn-3-one

: 14527-26-5,867-44-7,147895-43-0
2-methylisothiourea sulphate

: 1373425-71-8
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

Guidance literature:: With water; sodium carbonate; In ethyl acetate; for 3h; Reflux;
DOI:10.3998/ark.5550190.0013.310

Reference yield:

: 1352789-20-8
3-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranosyl-1-yl)propanal

: 1373425-71-8
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 h / 20 °C

3: water; sodium carbonate / ethyl acetate / 3 h / Reflux

With water; sodium carbonate; In tetrahydrofuran; ethyl acetate; 2: |Dess-Martin Oxidation;
DOI:10.3998/ark.5550190.0013.310

Reference yield:

: 1352789-39-9
(3R,S)-1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)pent-4-yn-3-ol

: 1373425-71-8
4-[2-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-β-D-ribofuranos-1-yl)ethyl]-2-methylthiopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

2: water; sodium carbonate / ethyl acetate / 3 h / Reflux

With water; sodium carbonate; In ethyl acetate; 1: |Dess-Martin Oxidation;
DOI:10.3998/ark.5550190.0013.310