1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine

Base Information

• Chemical Name: 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine
• CAS No.: 126225-72-7
• Molecular Formula: C₁₆H₁₆BrNO₄
• Molecular Weight: 366.211
• Mol file: 126225-72-7.mol

Synonyms:1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine

Chemical Property of 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine

There total 3 articles about 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-(2-bromobenzyl)-3,5-dimethoxycarbonylpyridinium bromide (126225-71-6) → 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine (126225-72-7)

Guidance literature:

With sodium dithionite; sodium carbonate; In water; Ambient temperature;

DOI:10.1016/S0040-4020(01)81101-7

Reference yield:

dimethyl pyridine-3,5-dicarboxylate (4591-55-3) → 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine (126225-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / methanol / 12 h / Heating

2: 57 percent / sodium dithionit, sodium carbonate / H₂O / Ambient temperature

With sodium dithionite; sodium carbonate; In methanol; water;

DOI:10.1016/S0040-4020(01)81101-7

Reference yield:

1-Bromo-2-bromomethyl-benzene (3433-80-5) → 1-(2-bromobenzyl)-1,4-dihydro-3,5-dimethoxycarbonylpyridine (126225-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / methanol / 12 h / Heating

2: 57 percent / sodium dithionit, sodium carbonate / H₂O / Ambient temperature

With sodium dithionite; sodium carbonate; In methanol; water;

DOI:10.1016/S0040-4020(01)81101-7

upstream raw materials:

1-(2-bromobenzyl)-3,5-dimethoxycarbonylpyridinium bromide

dimethyl pyridine-3,5-dicarboxylate

1-Bromo-2-bromomethyl-benzene

Downstream raw materials:

1-benzyl-1,4-dihydro-3,5-dimethoxycarbonylpyridine

(S)-1,2,6,10b-Tetrahydro-pyrido[2,1-a]isoindole-1,3-dicarboxylic acid dimethyl ester