(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester
CAS No.:206123-98-0
Molecular Formula:C₂₁H₃₁N₃O₅S
Molecular Weight:437.56
Hs Code.:

Synonyms:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Suppliers and Price of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

There total 3 articles about (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2280-66-2
N-tert-butyloxycarbonylalanylphenylalanine methyl ester

: 184951-86-8
(S)-tert-butyl (1-(6-nitro-1H-benzo[d][1,2,3]triazol-1-yl)-1-thioxopropan-2-yl)carbamate

: 206123-98-0
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Guidance literature:: N-tert-butyloxycarbonylalanylphenylalanine methyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

(S)-tert-butyl (1-(6-nitro-1H-benzo[d][1,2,3]triazol-1-yl)-1-thioxopropan-2-yl)carbamate; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h; Further stages.;
DOI:10.1021/jo010904i

Reference yield:

: 2280-66-2
N-tert-butyloxycarbonylalanylphenylalanine methyl ester

: 206123-98-0
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA

2: PyBOP, DIEA

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
DOI:10.1016/S0960-894X(98)00100-0

Reference yield:

: 40298-89-3,97336-13-5,102606-46-2,127214-08-8
L-alanyl-L-phenylalanine methyl ester

: (S)-2-tert-Butoxycarbonylamino-dithiopropionic acid

: 206123-98-0
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-propionylamino]-3-phenyl-propionic acid methyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Yield given;
DOI:10.1016/S0960-894X(98)00100-0