((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane
CAS No.:1388144-87-3
Molecular Formula:C₃₂H₄₈O₅Si
Molecular Weight:540.816
Hs Code.:

Synonyms:((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Suppliers and Price of ((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

There total 10 articles about ((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1388144-86-2
(S)-1-((4R,5R)-5-((R)-4-(tert-butyldiphenylsilanyloxy)pentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol

: 107-30-2
chloromethyl methyl ether

: 1388144-87-3
((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2012.05.017

Reference yield:

: 1388144-80-6
((R)-6-(4-methoxybenzyloxy)hexan-2-yloxy)(tert-butyl)diphenylsilane

: 1388144-87-3
((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: sodium hydride / diethyl ether; mineral oil / 0.17 h / -5 °C

3.2: 4 h / -5 - 20 °C

4.1: AD-mix-β; methanesulfonamide / water; tert-butyl alcohol

5.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

7.1: titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol / dichloromethane / 72 h / -78 - -20 °C / Molecular sieve

7.2: 1 h

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With titanium(IV) isopropylate; oxalyl dichloride; methanesulfonamide; AD-mix-β; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; water; toluene; mineral oil; tert-butyl alcohol; 2.1: Swern oxidation / 2.2: Swern oxidation / 3.2: Horner-Wadsworth-Emmons olefination / 4.1: Sharpless dihydroxylation / 7.1: Keck allylation;
DOI:10.1016/j.tetasy.2012.05.017

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 1388144-87-3
((R)-5-((4R,5R)-5-((S)-1-(methoxymethoxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-yloxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / -78 °C

2.2: -78 °C

3.1: magnesium / diethyl ether / Reflux

3.2: 2 h / -78 - 20 °C

3.3: Cooling

4.1: chlorodicarbonyl(1-(isopropylamino)-2,3,4,5-tetraphenylcyclopentadienyl) ruthenium (II); potassium tert-butylate; sodium carbonate / toluene / 6 h / 20 °C / Inert atmosphere

5.1: methanol; potassium carbonate / 2 h / 20 °C

6.1: 1H-imidazole / dichloromethane / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 20 °C

8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

8.2: -78 - 20 °C

9.1: sodium hydride / diethyl ether; mineral oil / 0.17 h / -5 °C

9.2: 4 h / -5 - 20 °C

10.1: AD-mix-β; methanesulfonamide / water; tert-butyl alcohol

11.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C

12.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

13.1: titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol / dichloromethane / 72 h / -78 - -20 °C / Molecular sieve

13.2: 1 h

14.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With 1H-imidazole; titanium(IV) isopropylate; methanol; chlorodicarbonyl(1-(isopropylamino)-2,3,4,5-tetraphenylcyclopentadienyl) ruthenium (II); oxalyl dichloride; methanesulfonamide; AD-mix-β; potassium tert-butylate; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium hydride; diisobutylaluminium hydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; magnesium; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; mineral oil; tert-butyl alcohol; 2.1: Swern oxidation / 2.2: Swern oxidation / 8.1: Swern oxidation / 8.2: Swern oxidation / 9.2: Horner-Wadsworth-Emmons olefination / 10.1: Sharpless dihydroxylation / 13.1: Keck allylation;
DOI:10.1016/j.tetasy.2012.05.017