(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid
CAS No.:1026874-47-4
Molecular Formula:C₁₈H₂₁NO₆
Molecular Weight:347.368
Hs Code.:

Synonyms:(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

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Chemical Property of (S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

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Technology Process of (S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

There total 3 articles about (S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.4%

: (R,S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid methyl ester

: 1026874-47-4
(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

Guidance literature:: With alcalase 2.4L; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 2.5h;
DOI:10.1021/jm010206q

Reference yield:

: 618-89-3
methyl 3-bromobenzoate

: 1026874-47-4
(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / (Ph₃P)2PdCl₂; Et₃N / 2 h / Heating

2: 39.4 percent / Alcalase 2.4L; aq. NaHCO₃ / acetonitrile / 2.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; alcalase 2.4L; sodium hydrogencarbonate; triethylamine; In acetonitrile;
DOI:10.1021/jm010206q

Reference yield:

: 71460-02-1,173306-82-6
methyl 2-[((1,1-dimethylethoxy)carbonyl)amino]-4-pentynoate

: 1026874-47-4
(S)-2-(tert-butoxycarbonylamino)-5-(3-carbomethoxyphenyl)-4-pentynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / (Ph₃P)2PdCl₂; Et₃N / 2 h / Heating

2: 39.4 percent / Alcalase 2.4L; aq. NaHCO₃ / acetonitrile / 2.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; alcalase 2.4L; sodium hydrogencarbonate; triethylamine; In acetonitrile;
DOI:10.1021/jm010206q