ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

Base Information

Chemical Name:ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate
CAS No.:80504-94-5
Molecular Formula:C₁₈H₂₇NO₆
Molecular Weight:354.404
Hs Code.:

Synonyms:ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

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Chemical Property of ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

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Technology Process of ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

There total 1 articles about ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 80504-94-5
ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Me₂CHMgBr / tetrahydrofuran / 1 h / Heating

2: tetrahydrofuran / 1.) 20 deg C, 30 min, 2.) reflux, 2 h

With isopropylmagnesium bromide; In tetrahydrofuran;
DOI:10.1039/P19810002786

Reference yield:

: 80504-94-5
ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

: 80504-97-8
benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<5-13C>pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent

2: 86.1 percent

4: MeOH, H₂SO₄ / 16 h

With methanol; sulfuric acid;
DOI:10.1039/P19810002786

Reference yield:

: 80504-94-5
ethyl 4-t-butoxycarbonyl-3-(2-ethoxycarbonylethyl)-5-methyl<5-13C>pyrrole-2-carboxylate

: 80505-10-8
benzyl 5-formyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl<5-13C>pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent

2: 86.1 percent

4: MeOH, H₂SO₄ / 16 h

5: 1) sulphuryl chloride, 2.) H₂O / 1.) CH₂Cl₂, 20 deg C, 2 h, 2.) acetone, 30 min

With methanol; sulfuryl dichloride; sulfuric acid; water;
DOI:10.1039/P19810002786