benzyl (3R)-3-trimethylsilylbutanoate

Base Information

Chemical Name:benzyl (3R)-3-trimethylsilylbutanoate
CAS No.:144050-21-5
Molecular Formula:C₁₄H₂₂O₂Si
Molecular Weight:250.413
Hs Code.:

Synonyms:benzyl (3R)-3-trimethylsilylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3R)-3-trimethylsilylbutanoate

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Technology Process of benzyl (3R)-3-trimethylsilylbutanoate

There total 8 articles about benzyl (3R)-3-trimethylsilylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 144125-26-8
N-[(E)-(3'R)-3'-trimethylsilylbutanoyl]-(7R)-2,10-camphorsultam

: 100-51-6,185532-71-2
benzyl alcohol

: 144050-21-5
benzyl (3R)-3-trimethylsilylbutanoate

Guidance literature:: benzyl alcohol; With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.166667h;

N-[(E)-(3'R)-3'-trimethylsilylbutanoyl]-(7R)-2,10-camphorsultam; In tetrahydrofuran; diethyl ether; at 20 ℃; for 20h; Further stages.;
DOI:10.1039/b313446f

Reference yield: 96.0%

: benzyloxymagnesium bromide

: 144125-26-8
N-[(E)-(3'R)-3'-trimethylsilylbutanoyl]-(7R)-2,10-camphorsultam

: 144050-21-5
benzyl (3R)-3-trimethylsilylbutanoate

Guidance literature:: In tetrahydrofuran; for 20h; Ambient temperature;
DOI:10.1016/S0040-4039(00)60115-6

Reference yield:

: 144050-19-1
(7S)-N-<(2E)-3-Trimethylsilylprop-2-enoyl>-D-2,10-camphorsultam

: 144050-21-5
benzyl (3R)-3-trimethylsilylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: CuI; Bu₃P / diethyl ether / 0.33 h / -20 °C

1.2: EtAlCl₂ / diethyl ether; hexane / 0.33 h / -78 °C

1.3: 93 percent / diethyl ether; hexane / 2 h

2.1: 74 percent / H₂O₂; aq. LiOH / tetrahydrofuran / 2 h / 20 °C

3.1: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

4.1: NaH / toluene; hexane / 1 h

4.2: 10.2 g / toluene; hexane / 2 h

5.1: MeMgBr / diethyl ether; tetrahydrofuran / 0.17 h / 0 °C

5.2: 96 percent / diethyl ether; tetrahydrofuran / 20 h / 20 °C

With lithium hydroxide; copper(l) iodide; oxalyl dichloride; tributylphosphine; methylmagnesium bromide; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1039/b313446f