3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

Base Information

Chemical Name:3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester
CAS No.:1053623-03-2
Molecular Formula:C₃₂H₃₆N₂O₅
Molecular Weight:528.648
Hs Code.:

Synonyms:3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

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Chemical Property of 3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

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Technology Process of 3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

There total 1 articles about 3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 170028-72-5
(3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

: 1053623-03-2
3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / 1,2-dichloro-ethane / 16 h / Heating

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 48 h

With sodium hydride; In 1,2-dichloro-ethane;
DOI:10.1021/jm970288b

Reference yield: 54.0%

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 1053623-03-2
3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

: 1054795-51-5
3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-benzoic acid methyl ester

Guidance literature:: In acetonitrile; for 72h; Heating;
DOI:10.1021/jm970288b

Reference yield:

: 1053623-03-2
3-((3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-3a,4,8,8a-tetrahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl)-benzoic acid methyl ester

: 1053732-20-9
3-[(3aS,4R,8R,8aS)-7-(3-Amino-benzyl)-4,8-dibenzyl-2,2-dimethyl-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-tert-butyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / acetonitrile / 72 h / Heating

2: trimethylaluminum / 1,2-dichloro-ethane / 24 h / Heating

3: ammonium formate / 10percent Pd/C / 2-methyl-propan-2-ol / Ambient temperature

With trimethylaluminum; ammonium formate; palladium on activated charcoal; In 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm970288b