tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate
CAS No.:1315464-51-7
Molecular Formula:C₂₂H₂₃F₃N₆O₃
Molecular Weight:476.458
Hs Code.:

Synonyms:tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

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Chemical Property of tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

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Technology Process of tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

There total 7 articles about tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315465-35-0
tert-butyl 2-(4-(5-amino-6-cyano-4-(methylamino)pyridin-2-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

: 1315464-51-7
tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; at 20 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1315464-51-7
tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum oxide / 0.17 h / 20 °C

2: triethylamine; sodium hydride / N,N-dimethyl-formamide / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

5: hydrogenchloride; sodium nitrite / water / 1 h / 20 °C

With hydrogenchloride; aluminum oxide; potassium phosphate; potassium acetate; sodium hydride; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 57561-39-4
methyl(2-hydroxyethyl)carbamic acid tert-butyl ester

: 1315464-51-7
tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; sodium hydride / N,N-dimethyl-formamide / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / water / 1 h / 20 °C

With hydrogenchloride; potassium phosphate; potassium acetate; sodium hydride; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;