Technology Process of 4-[5-(2,2-Dipropoxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole
There total 6 articles about 4-[5-(2,2-Dipropoxy-ethyl)-benzofuran-2-ylmethyl]-5-methyl-2-phenyl-oxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / Cu2O, (PPh3)2PdCl2, pyridine / Heating
2: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h
3: p-TsOH*H2O / Heating
With
pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; toluene-4-sulfonic acid; lithium diisopropyl amide;
DOI:10.1021/jm960230h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) pyridine, 2.) H2O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min
2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C
3: 65 percent / Cu2O, (PPh3)2PdCl2, pyridine / Heating
4: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h
5: p-TsOH*H2O / Heating
With
pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; water; toluene-4-sulfonic acid; trifluoroacetic anhydride; lithium diisopropyl amide;
In
trifluoroacetic acid;
DOI:10.1021/jm960230h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C
2: 65 percent / Cu2O, (PPh3)2PdCl2, pyridine / Heating
3: 1.) LDA / 1.) THF, hexane, -10 deg C, 1 h, 2.) THF, hexane, from -10 deg C to RT, 2 h
4: p-TsOH*H2O / Heating
With
pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; toluene-4-sulfonic acid; trifluoroacetic anhydride; lithium diisopropyl amide;
In
trifluoroacetic acid;
DOI:10.1021/jm960230h
