N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Chemical Name:N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide
CAS No.:1160625-08-0
Molecular Formula:C₃₁H₂₇ClF₂N₆O₂S
Molecular Weight:621.11
Hs Code.:

Synonyms:N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Chemical Property of N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

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Technology Process of N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

There total 1 articles about N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 895637-64-6,1160622-95-6
{2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine hydrochloride

: 1160625-05-7
N-(3-(5-(2-chloro-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

: 1160625-08-0
N-(3-(5-(2-((3-chloro-4-((2-(dimethylamino)ethyl)oxy)phenyl)amino)-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

Guidance literature:: {2-[(4-amino-2-chlorophenyl)oxy]ethyl}dimethylamine hydrochloride; N-(3-(5-(2-chloro-4-pyrimidinyl)-2-methyl-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide; With hydrogenchloride; In isopropyl alcohol; at 185 ℃; for 0.5h;

With water; sodium hydrogencarbonate; In dichloromethane; isopropyl alcohol;