2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

Base Information

Chemical Name:2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione
CAS No.:1262052-77-6
Molecular Formula:C₂₃H₂₂O₇
Molecular Weight:410.423
Hs Code.:

Synonyms:2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

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Chemical Property of 2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

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Technology Process of 2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

There total 11 articles about 2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 69008-03-3
2-bromo-5-hydroxy-[1,4]naphthoquinone

: (2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)tributylstannane

: 1262052-77-6
2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; at 20 - 75 ℃; for 12h;
DOI:10.1002/anie.201005329

Reference yield:

: 329788-95-6
3-methyl-5-(2-tetrahydropyranyloxy)benzaldehyde

: 1262052-77-6
2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: n-butyllithium / hexane / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 80 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1002/chem.201301297

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1262052-77-6
2-(2-(1,3-dioxan-2-yl)-6-(methoxymethoxy)-4-methylphenyl)-5-hydroxynaphthalene-1,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 20 °C

2: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: Dess-Martin periodane / dichloromethane / 20 °C

5: toluene-4-sulfonic acid / toluene / Reflux

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7: n-butyllithium / hexane / 0 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 80 °C

With copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; pyridinium p-toluenesulfonate; Dess-Martin periodane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1002/chem.201301297