Technology Process of 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-2,3,8,9,10,11-hexahydro-1H,7aH-pyrrolo[2,1-j]quinolin-7-one
There total 20 articles about 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-2,3,8,9,10,11-hexahydro-1H,7aH-pyrrolo[2,1-j]quinolin-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium cyanoborohydride;
In
methanol; diethyl ether;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol053059p
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / N-chlorosuccinimide; H2O / 2-methyl-propan-2-ol / 1 h / 20 °C
2: 66 percent / N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 4 h / 20 °C
3: 98 percent / Zn; HOAc / 2 h / 20 °C
4: H2 / 10 percent Pd/C / ethanol / 48 h / 2585.74 Torr
5: aq. HCl; NaCNBH4 / methanol; diethyl ether / 20 °C
With
hydrogenchloride; N-chloro-succinimide; tetrapropylammonium perruthennate; 4 A molecular sieve; water; hydrogen; sodium cyanoborohydride; acetic acid; 4-methylmorpholine N-oxide; zinc;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; dichloromethane; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: pyridine / 20 °C
2: 100 percent / TFA / CH2Cl2 / 1 h / 0 °C
3: 61 percent / pyridine / ethanol / 48 h / Heating
4: K2CO3 / methanol; H2O / 1 h / 20 °C
5: 504.0 mg / N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 20 °C
6: 68 percent / Na2SO4; piperidinium acetate / ethyl acetate; toluene / Heating
7: 76 percent / N-chlorosuccinimide; H2O / 2-methyl-propan-2-ol / 1 h / 20 °C
8: 66 percent / N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 4 h / 20 °C
9: 98 percent / Zn; HOAc / 2 h / 20 °C
10: H2 / 10 percent Pd/C / ethanol / 48 h / 2585.74 Torr
11: aq. HCl; NaCNBH4 / methanol; diethyl ether / 20 °C
With
pyridine; hydrogenchloride; N-chloro-succinimide; tetrapropylammonium perruthennate; 4 A molecular sieve; water; hydrogen; piperdinium acetate; sodium cyanoborohydride; potassium carbonate; acetic acid; 4-methylmorpholine N-oxide; sodium sulfate; trifluoroacetic acid; zinc;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene; tert-butyl alcohol;
