(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

Base Information

Chemical Name:(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide
CAS No.:89824-40-8
Molecular Formula:C₁₈H₂₄N₂O₃
Molecular Weight:316.4
Hs Code.:

Synonyms:(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

Chemical Property:

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Technology Process of (αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

There total 10 articles about (αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

: 73331-65-4,73365-64-7,75556-14-8,75556-15-9,75556-16-0,75597-57-8,89824-38-4,89824-39-5
(αR,2S,5R)-N-tert-Butyl-2,5-dihydro-5-methyl-α-(N-(S)-(α-methylbenzyl)benzamido)-2-furanacetamide

: 89824-40-8
(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

Guidance literature:: With formic acid; 1) 2h, rt, 2) 2h, 60 deg C;
DOI:10.1021/jo00184a020

Reference yield:

: 73080-49-6
2,5-Anhydro-D-mannose-dimethylacetal

: 89824-40-8
(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 65.4 percent / Pyridine / CHCl₃ / 5 °C

2: 80.2 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 78 percent / Pyridine / 96 h / 0 °C

4: 80.7 percent / NaI, Zn(dust) / dimethylformamide / 4 h / 140 °C

5: p-Toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 3 h / Heating

6: methanol / Ambient temperature

7: 96.1 percent / Formic acid / 1) 2h, rt, 2) 2h, 60 deg C

With pyridine; lithium aluminium tetrahydride; formic acid; toluene-4-sulfonic acid; sodium iodide; zinc; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00184a020

Reference yield:

: 1078691-95-8
(+)-D-glucosamine hydrochloride

: 89824-40-8
(αR,2S,5R)-α-Benzamido-N-tert-butyl-2,5-dihydro-5-methyl-2-furanacetamide

Guidance literature:: Multi-step reaction with 9 steps

1: N₂O₃, H₂O

2: methanol / Heating

3: 65.4 percent / Pyridine / CHCl₃ / 5 °C

4: 80.2 percent / LiAlH₄ / tetrahydrofuran / Heating

5: 78 percent / Pyridine / 96 h / 0 °C

6: 80.7 percent / NaI, Zn(dust) / dimethylformamide / 4 h / 140 °C

7: p-Toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 3 h / Heating

8: methanol / Ambient temperature

9: 96.1 percent / Formic acid / 1) 2h, rt, 2) 2h, 60 deg C

With pyridine; lithium aluminium tetrahydride; formic acid; dinitrogen trioxide; water; toluene-4-sulfonic acid; sodium iodide; zinc; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00184a020