Technology Process of deprotected 9
There total 9 articles about deprotected 9 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C36H52N2O10Si;
With
methanol; toluene-4-sulfonic acid;
at 70 ℃;
for 1h;
With
triethylamine;
In
methanol;
at 20 ℃;
DOI:10.1021/ol2021687
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / acetonitrile / 3 h / 20 °C
2.1: sodium hydride / 1,4-dioxane / 60 °C / Inert atmosphere
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.1: methanol; toluene-4-sulfonic acid / 1 h / 70 °C
4.2: 20 °C
With
methanol; dmap; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/ol2021687
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride / water / 6 h / 80 °C
2.1: pyridine / 0 - 20 °C / Inert atmosphere
3.1: dmap / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere
4.1: methanol; sodium methylate / 12 h / 20 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / acetonitrile / 3 h / 20 °C
6.1: sodium hydride / 1,4-dioxane / 60 °C / Inert atmosphere
7.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere
8.1: methanol; toluene-4-sulfonic acid / 1 h / 70 °C
8.2: 20 °C
With
pyridine; hydrogenchloride; methanol; dmap; sodium methylate; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol2021687
