1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine

Base Information

• Chemical Name: 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine
• CAS No.: 113817-51-9
• Molecular Formula: C₁₅H₈N₂O₆
• Molecular Weight: 312.238

Synonyms:1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine

Chemical Property of 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine

Chemical Property:

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Technology Process of 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine

There total 2 articles about 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,8-hexahydro(difuro)-<3,4,3',4'-b,e>pyridine (113817-50-8) → 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine (113817-51-9)

Guidance literature:

With potassium permanganate; In acetone; toluene; for 3h; Heating;

DOI:10.1002/ardp.19913240209

Reference yield:

nifedipine (21829-25-4) → 1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine (113817-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / N-bromosuccinimide / CHCl₃ / 0.5 h / Heating

2: 48 percent / 3N nitric acid / 2 h

With N-Bromosuccinimide; nitric acid; In chloroform;

DOI:10.1007/BF00475365

Reference yield: 74.0%

1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,-tetrahydro(difuro)-<3,4,3',4'-b,e>pyridine (113817-51-9) → 8-(2-Aminophenyl)-1,3,4,5,7,8-hexahydro-difuro<3,4-b:3',4'-e>pyridin-1,7-dion (133082-72-1)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; water; for 2h; Ambient temperature;

DOI:10.1002/ardp.19913240209

upstream raw materials:

1,7-dioxo-8-(o-nitrophenyl)-1,3,4,5,7,8-hexahydro(difuro)-<3,4,3',4'-b,e>pyridine

nifedipine

Downstream raw materials:

8-(2-Aminophenyl)-1,3,4,5,7,8-hexahydro-difuro<3,4-b:3',4'-e>pyridin-1,7-dion

8-(2-Amino-3,5-dichlorphenyl)-1,3,5,7-tetrahydro-difuro<3,4-b:3',4'-e>pyridin-1,7-dion

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